Probiotics can confer many benefits such as immunomodulation, lipid and cholesterol reduction, anticancer, antimicrobial and antioxidative properties, prevention of gastrointestinal infections, improvement of lactose metabolism, etc. Probiotics are defined by the Food and Agriculture Organization (FAO) of the United Nations and the World Health Organization (WHO) as “live microorganisms which when administered in adequate amounts confer a health benefit on the host”. Some LAB are commonly considered probiotics and generally recognized as safe (GRAS). There are many species of LAB, including Enterococcus, Lactobacillus, Pediococcus, Streptococcus, Lactococcus, Vagococcus, Leuconostoc, Oenococcus, Weissella, Carnobacterium and Tetragenococcus, which are general microflora in both human and animal GITs. Lactic acid bacteria (LAB) are a group of lactic-acid-producing, Gram-positive, non-spore-forming, catalase-negative, anaerobic or microaerophilic, cocci or rods. coryniformis NA-3 showed potential probiotic properties, and the heat-killed strain also exhibited activities similar to those of live bacteria, suggesting the possible value of its further application in the food processing and pharmaceutical industries. The increased expression of inducible nitric oxide synthase (iNOS) in treated macrophages mediates the production of NO. coryniformis NA-3, the production of NO, IL-6, TNF-α and reactive oxygen species (ROS) was induced. After RAW 264.7 macrophages were treated with live and heat-killed L. coryniformis NA-3 can significantly inhibit the proliferation of colon cancer cells however, dead cells cannot. coryniformis NA-3 can scavenge free radicals as well as live strains. coryniformis NA-3 has antibacterial activity and cholesterol removal ability and is sensitive to most antibiotics. The potential anticancer and immunoregulatory capacity was determined in vitro using cell lines. coryniformis NA-3 were assessed via radicals’ scavenging ability. The antioxidant activities of live and heat-killed L. Coculture, the Oxford cup test and disk-diffusion methods were used to evaluate the probiotic properties and antibiotic resistance of L. Loigolactobacillus coryniformis NA-3 obtained from our laboratory is a promising probiotic according to the previous study. Some Latiactobacilli are often used as probiotics due to their functional activities, including antioxidant, anticancer and immunoregulation effect.
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